Dias-Baptista, Ida Maria FoschianiUsó, S. M.R.S.Marcondes-Machado, J. [UNESP]2022-04-282022-04-282008-01-01Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 14, n. 2, p. 203-223, 2008.1678-9199http://hdl.handle.net/11449/225187Multidrug-resistant tuberculosis (MDR-TB) is an increasing global problem. The extent and burden of MDR-TB varies significantly from country to country and region to region. Globally, about three per cent of all newly diagnosed patients have MDR-TB and the proportion is higher in patients who had previously received anti-tuberculosis (anti-TB) treatment reflecting the failure of programs designed to ensure complete cure of patients with tuberculosis. The management of MDR-TB is a challenge that should be undertaken by experienced clinicians at centers equipped with reliable laboratory services and implementation of DOTS-Plus strategy.203-223engDOTSDOTS-PlusMDR-TBTuberculosisXDR-TBResenha10.1590/S1678-919920070075000012-s2.0-45349105673