Tiera, Marcio J. [UNESP]Shi, QinGoncalves Barbosa, Hellen Franciane [UNESP]Fernandes, Julio C.2014-12-032014-12-032013-10-01Current Gene Therapy. Sharjah: Bentham Science Publ Ltd, v. 13, n. 5, p. 358-369, 2013.1566-5232http://hdl.handle.net/11449/112928The delivery of small interfering RNAs (siRNAs) is a promising approach to silencing gene expression aimed at treating infections, cancer, neurodegenerative diseases and various other disorders. Recent progress in this area has been achieved with nanodevices possessing multiple properties and assembled with new, biodegradable, synthetic polymers and polysaccharides. Different synthetic routes and multiple strategies, such as multilayer systems and stimuli-responsive polymers, have been developed to attain high efficiencies. This review covers the most important, promising and successful approaches to improve siRNA delivery. It is a concise report on multiple strategies employed, including cell-specific delivery coupling ligands or antibodies with nanodevices to improve siRNA efficiency and specificity.358-369engGene therapynanoparticlesmultifunctionalpolycationsstimuli-responsive polymerssiRNA deliveryArtigoWOS:000328562300006Acesso restrito