Bedran de Castro, J. C.Petrovic, S. L.McCann, S. M.2014-05-272014-05-271986-01-01Brain Research, v. 384, n. 1, p. 11-16, 1986.0006-8993http://hdl.handle.net/11449/63759Many experiments have been performed to evaluate the physiological role of catecholaminergic mechanisms of gonadotropin release. The purpose of the present study was to determine the concentration of β-adrenoreceptors in the remaining (right) cerebral cortex and in right and left hypothalamic halves of hemi-decorticated female rats which exhibited elevated plasma gonadotropin levels as observed previously. The density of β-receptors was measured using a high-affinity β-adrenergic ligand, iodocyanopindolol (ICYP). Scatchard estimates were obtained for maximum binding (B(max) fmol/mg of tissues) from pooled cerebral cortical and hypothalamic tissue of animals under several experimental conditions after hemi-decortication and sham operation. There was an increase in β-adrenoreceptor density in the remaining (right) cerebral cortex at all times examined in hemi-decorticate in comparison with the sham-operated animals (7 days, +10.9%; 21 days, +8.4%; 90 days, +22%; and 90 days plus ovariectomy, +34.8%). The number of β-adrenoreceptors in the right hypothalamic half in hemi-decorticates decreased at 21 days (-42.20%) and then increased at 90 days (+76.63%) and 90 days plus ovariectomy (+51.75%) when compared with the left hypothalamic half. At the same time there were no significant changes in the sham-operated animals when comparing the receptor density in the right and left hypothalamic halves, respectively. Thus, our results suggest a direct adrenergic pathway by which the left cortex can influence the right cortex and a crossed pathway to the contralateral hypothalamus changing adrenergic activity which can alter the β-adrenergic receptor binding capacity in the hypothalamus.11-16engbeta adrenergic receptorcyanoiodopindololcyanopindolol i 125propranololradioisotopeanimal cellanimal experimentbrain cortexcentral nervous systemdecorticationdrug receptor bindingendocrine systemestrusfemale genital systemhypothalamusnonhumanovariectomypharmacokineticspriority journalratrhinencephalonAnimalCerebral CortexFemaleHypothalamusLateralityRadioligand AssayRatsRats, Inbred StrainsReceptors, Adrenergic, betaSupport, Non-U.S. Gov'tSupport, U.S. Gov't, P.H.S.Time FactorsArtigo10.1016/0006-8993(86)91213-8Acesso restrito2-s2.0-0022451485