Ferriani, Rui A.Andrade, Rosires P.Neto, Luiz FerrazNakagava, Hitomi M.Dias, Rogerio [UNESP]Finotti, Marta F.Bacarat, Edmund C.Freitas, Fernando M.Tadini, ValdirNeto, Antônio Aleixo2014-05-272014-05-272006-04-01Revista Brasileira de Medicina, v. 63, n. 4, p. 144-151, 2006.0034-7264http://hdl.handle.net/11449/68833Background: To assess satisfaction with the weekly transdermal contraceptive patch, compared to the previous contraceptive method. Adhesion, cycle control, safety and efficacy were secondary outcomes. Methods: A multicenter, open label, descriptive study. Subjects received the weekly transdermal contraceptive patch for 6 cycles. At the baseline and after the 1 st, 3 rd and 6 th cycles, satisfaction with the method was assessed. The contraceptive efficacy was assessed by the Pearl Index and by life table analysis. Results: An ITT analysis was performed with 494 subjects. At the endpoint, 95.3% of women were satisfied with the patch compared to the previous method; 59.5%, 58.0% and 63.2% of women reported improvement in the physical and emotional well-being, and pre-menstrual symptoms, respectively. Pre-menstrual symptoms frequency decreased from 85.0% (CI 95%: 80.8-87.4%) to 55.0% (CI 95%: 49.9-66.0%). There was a significant increase in hemoglobin levels, and also a significant decrease in total serum cholesterol and tryglicerides.. There were no significant adverse events. The adjusted Pearl Index was 1.1 pregnancies per 100 women-years. Conclusions: The weekly contraceptive transdermal patch is a safe and effective method, and there was a high rate of satisfaction with its use among brazilian women. The patch was associated to a good cycle control, with easiness of use, improvement in the physical and emotional well-being and improvement in the premenstrual symptoms and lipid profile. © Copyright Moreira Jr. Editora. Todos os direitos reservados.144-151porcholesterolcontraceptive agenthemoglobintriacylglyceroladultcholesterol blood levelcontraceptioncontrolled studyemotionfemalehumanhuman experimentmenstrual cyclepregnancypremenstrual syndromesafetysatisfactiontransdermal patchtriacylglycerol blood levelArtigoAcesso aberto2-s2.0-337449127919476843874583499