Borin, AndreiAbib Jr., EduardoAraujo, Cleomines IzidioMartinez, Luis Lopez [UNESP]Rodrigues, Heloisio2014-05-272014-05-272009-12-01Brazilian Journal of Otorhinolaryngology, v. 75, n. 6, 2009.1808-86941808-8686http://hdl.handle.net/11449/71343Clinical studies on nasal topical medications require the standardization of nasosinusal normality in order to establish control groups through a specific evaluation of the upper airways. Aim: to standardize the evaluation of candidates for control groups in clinical studies on nasal topical medications. Material and Methods: healthy male volunteers of 18 to 50 years of age, asymptomatic from the nasosinusal standpoint were subjected to a sequential and excluding assessment made up of clinical evaluation, immediate hypersensitivity skin test, saccharin test, flexible nasofibroscopy and nasal cytology. Study design: Crosssectional contemporary cohort. Results: Of the 33 people originally enrolled, 14 (42.4%) were excluded for clinical reasons. Of the 19 remaining, 2 (10.5%) had atopy diagnosed in the skin test and were excluded. 17 were tested with saccharin and presented normal mucociliary clearance. Evaluation by nasal endoscopy showed abnormality in 2 cases (11.8%) and these were excluded. The remaining 15 were submitted to nasal cytology, which proved normal, representing 45.5% of those initially included. Conclusion: The proposed protocol for sequential and excluding evaluation was effective in defining candidates for the establishment of control groups in clinical studies on nasal topical medications. © Revista Brasileira de Otorrinolaringologia. All Rights reserved.porControl groupsCytologyMucociliary clearanceNoseSkin testsdiagnostic agentsaccharinadolescentadultcase control studycross-sectional studyhumanimmediate type hypersensitivityintranasal drug administrationmalemiddle agedmucociliary clearancepatient selectionskin testAdministration, IntranasalAdolescentAdultCase-Control StudiesCross-Sectional StudiesHumansHypersensitivity, ImmediateMaleMiddle AgedMucociliary ClearancePatient SelectionSaccharinSkin TestsYoung AdultArtigo10.1590/S1808-86942009000600017S1808-86942009000600017Acesso aberto2-s2.0-776491607542-s2.0-77649160754.pdf