Touitou, MeirManetti, FabrizioRibeiro, Camila Maringolo [UNESP]Pavan, Fernando Rogerio [UNESP]Scalacci, NicolòZrebna, KatarinaBegum, NeeluSemenya, DorothyGupta, AntimaBhakta, SanjibMchugh, Timothy D.Senderowitz, HanochKyriazi, MelinaCastagnolo, Daniele2020-12-122020-12-122020-05-14ACS Medicinal Chemistry Letters, v. 11, n. 5, p. 638-644, 2020.1948-5875http://hdl.handle.net/11449/201456A series of N-phenyl-2,5-dimethylpyrrole derivatives, designed as hybrids of the antitubercular agents BM212 and SQ109, have been synthesized and evaluated against susceptible and drug-resistant mycobacteria strains. Compound 5d, bearing a cyclohexylmethylene side chain, showed high potency against M. tuberculosis including MDR-TB strains at submicromolar concentrations. The new compound shows bacteriostatic activity and low toxicity and proved to be effective against intracellular mycobacteria too, showing an activity profile similar to isoniazid.638-644engantimycobacterial drugdrug resistanceintracellular tuberculosispyrrolesTuberculosisArtigo10.1021/acsmedchemlett.9b005152-s2.0-85077653042