Fernandes, Felipe Hugo Alencar [UNESP]Soares, Sabrina da SilvaBekbolatova, ElmiraBoylan, FábioSalgado, Hérida Regina Nunes [UNESP]2023-07-292023-07-292023-01-01Natural Product Research.1478-64271478-6419http://hdl.handle.net/11449/249939Spondias dulcis Parkinson have been used in traditional medicine in Asia, Oceania, and South America, for different diseases conditions and as a functional food. The scientific literature described as different potential pharmacology such as antioxidant, anti-inflammatory, antimicrobial, thrombolytic and enzymatic inhibitor. This study aimed to: (1) establish the pharmacological activity in intestinal motility in vivo and antioxidant activity in vitro; (2) perform the acute toxicology test in mouse; (3) characterize the phytochemical profile based on counter-current chromatography (CCC) and NMR analysis. The results revealed a laxative effect of S. dulcis extract and a high antioxidant activity (IC50 = 5.10 for DPPH assay and 14.14 for hydrogen peroxide scavenging test). No side effects were observed in the oral acute toxicity test for a dose up to 2000 mg/kg. The chemical profile was identified by CCC and NMR, and the comparison of the data obtained with previous literature revealed the presence of the flavonoid rutin (Quercetin-3-O-rutinoside) in the extract.engantioxidant activitycountercurrent chromatographyLaxative activityrutinArtigo10.1080/14786419.2023.22102542-s2.0-85158923284