Minicucci, Marcos Ferreira [UNESP]Gaiolla, Paula Schmidt Azevedo [UNESP]Polegato, Bertha Furlan [UNESP]Paiva, Sergio A.R. [UNESP]Zornoff, Leonardo Antonio Mamede [UNESP]2014-05-272014-05-272012-12-04Inflammation and Allergy - Drug Targets, v. 11, n. 6, p. 442-447, 2012.1871-5281http://hdl.handle.net/11449/74048Cardiac or ventricular remodeling is characterized by molecular, cellular, and interstitial alterations that lead to changes in heart size, mass, geometry and function in response to a given insult. Currently, tobacco smoke exposure is recognized as one of these insults. Indeed, tobacco smoke exposure induces the enlargement of the left-sided cardiac chambers, myocardial hypertrophy, and ventricular dysfunction. Potential mechanisms for these alterations include hemodynamic and neurohormonal changes, oxidative stress, inflammation, nitric oxide bioavailability, matrix metalloproteinases and mitogen-activated protein kinase activation. This review will focus on the concepts, relevance, and potential mechanisms of cardiac remodeling induced by tobacco smoke. © 2012 Bentham Science Publishers.442-447engMatrix metalloproteinasesOxidative stressTobacco smoke exposureVentricular remodelingacetylcysteineadenosine triphosphatebeta carotenecalcium channel L typecalcium iongamma interferongelatinase Binterleukin 1interleukin 18interleukin 6mitogen activated protein kinaseneurohormonenicotinenitric oxidereactive oxygen metabolitetaurinetobacco smoketumor necrosis factor alphavitamin Dcalcium mobilizationcytokine productionenergy metabolismexposureheart diseaseheart infarctionheart muscle contractilityheart sizeheart ventricle failureheart ventricle hypertrophyheart ventricle remodelinghemodynamic stresshypoxemiainflammationnonhumanoxidative stressrenin angiotensin aldosterone systemsmokingsupplementationAnimalsHumansInflammationMatrix MetalloproteinasesMitogen-Activated Protein KinasesNitric OxideOxidative StressSmokingVentricular Dysfunction, LeftVentricular RemodelingArtigo10.2174/187152812803589958Acesso restrito2-s2.0-848702578395016839015394547121314080140264774387040344716730000-0002-5843-6232