Mota, N. G S [UNESP]Viero, Rosa Marlene [UNESP]Rezkallah-Iwasso, M. T. [UNESP]Peraçoli, Maria Terezinha Serrão [UNESP]Soares, Ângela Maria Victoriano de Campos [UNESP]Montenegro, M. R. [UNESP]2014-05-262014-05-261984-12-01Mycopathologia, v. 88, n. 2-3, p. 141-148, 1984.0301-486X1573-0832http://hdl.handle.net/11449/63674The effect of Ketoconazole (KTZ) on the hamster experimental intratesticular paracoccidioidomycosis was studied employing different treatment schedules. KTZ long course treatment beginning at an early stage of the infection was effective in preventing fungal proliferation, dissemination to lymph nodes, spleen and kidneys, and in maintaining low levels of humoral and cellular specific immune responses. KTZ short course treatment starting at an advanced stage of disease resulted in a more severe histopathological picture without significant changes in the immunological profile. The drug prolonged the life span of hamsters infected with Paracoccidioides brasiliensis, but did not prevent mortality. Toxic necrosis of the bone marrow occurred in normal animals receiving 120 mg/kg/day of KTZ but with lower doses no morphologic alterations were observed in heart, lungs, kidneys, adrenals, spleen, liver, intestine or bone marrow. © 1984 Dr W. Junk Publishers.141-148engketoconazolephytohemagglutininanimal experimentdose responsedrug efficacydrug responsedrug therapydrug toxicityexperimental infectionhistologyintoxicationmethodologymycosisnonhumanoral drug administrationsouth american blastomycosistherapyAnimalsCell Migration InhibitionCricetinaeImmunodiffusionKetoconazoleMacrophagesMaleMesocricetusParacoccidioidomycosisAnimaliaMesocricetus auratusParacoccidioides brasiliensisArtigo10.1007/BF00436445Acesso restrito2-s2.0-002168999514535641713338486486557387397806