Medeiros, Alexandra Ivo de [UNESP]Secatto, AdrianaBelanger, CarolineSorgi, Carlos ArtérioBorgeat, PierreMarleau, SylvieFaccioli, Lucia Helena2015-10-212015-10-212015-01-01Biomed Research International. New York: Hindawi Publishing Corporation, v. 2015, p. 1-6, 2015.2314-6133http://hdl.handle.net/11449/129366Histoplasma capsulatum (Hc) induces a pulmonary disease in which leukotrienes promote activation and recruitment of effectors cells. It is also well-recognized that leukotriene B 4 (LTB 4) and platelet-activating factor (PAF) induce leukocyte recruitment to inflammatory sites. We investigated the impact of pulmonary Hc infection on PMN migration to a remote inflammatory site. Our results show that pulmonary Hc infection impairs LTB4- or PAF-stimulated PMN recruitment to air pouch. Yet, remote inflammation did not modify PMN numbers in the bronchoalveolar lavage fluid (BALF) of Hc-infected mice. Interestingly, the concomitant administration of PAF and LTB 4 receptor antagonists inhibited PMN recruitment to both BALF and the remote site, demonstrating cooperation between both mediators. Along that line, our results show that PAF-elicited PMN chemotaxis was abrogated in 5-lipoxygenase-deficient animals. These results suggest caution in the indiscriminate use of anti-inflammatory drugs during infectious diseases.1-6engArtigo10.1155/2015/409309WOS:000349213800001Acesso abertoWOS000349213800001.pdf