Cassettari, Vanessa Mello Granado [UNESP]Machado, Nilton Carlos [UNESP]Lourenção, Pedro Luiz Toledo de Arruda [UNESP]Carvalho, Marry Assis [UNESP]Ortolan, Erika Veruska Paiva [UNESP]2018-12-112018-12-112018-01-01Jornal de Pediatria.0021-7557http://hdl.handle.net/11449/176120Objectives: Evaluate the effect of combinations of green banana biomass and laxatives in children and adolescents with chronic constipation. Methods: This was a randomized study of 80 children and adolescents with functional constipation according to the Rome IV Criteria, who were divided into five groups: (1) green banana biomass alone; (2) green banana biomass plus PEG 3350 with electrolytes; (3) green banana biomass plus sodium picosulfate; (4) PEG 3350 with electrolytes alone; and (5) sodium picosulfate alone. Primary outcome measure was the reduction of the proportion of patients with Bristol Stool Form Scale ratings 1 or 2. Secondary outcome measures were: increase of the proportion of >3 bowel movements/week and reduction of the proportion of fecal incontinence, straining on defecation, painful defecation, blood in stool, abdominal pain, and decreased laxative doses. Results: On consumption of green banana biomass alone, a statistically significant reduction was observed in the proportion of children with Bristol Stool Form Scale rating 1 or 2, straining on defecation, painful defecation, and abdominal pain. Conversely, no reduction was observed in fecal incontinence episodes/week, blood in stool, and no increase was observed in the proportion of children with >3 bowel movements/week. The percentage of children who required decreased laxative dose was high when green banana biomass was associated with sodium picosulfate (87%), and PEG 3350 with electrolytes (63%). Green banana biomass alone and associated with laxatives was well tolerated, and no adverse effects were reported. Conclusion: Green banana biomass is advantageous as an adjunct therapy on functional constipation, mainly for reducing doses of laxatives.engConstipationDietary fiberGreen bananaGreen banana biomassResistant starchArtigo10.1016/j.jped.2017.10.011Acesso aberto2-s2.0-850447778342-s2.0-85044777834.pdf9204865367532468442852430555412447296037206288350000-0002-8753-646X0000-0002-9697-3450