Malaspina, Ana Carolina [UNESP]Cavalcanti, Hebe RodriguesLeite, Clarice Queico Fujimura [UNESP]Machado, Silvia Maria AlmeidaViana, Brunilde Helena JungSilva, Rosangela Maria GasparetoHage, Eduardo FerrazFigueiredo, Walter MachadoMarques, ElisabethFerrazoli, LucilaineArbex, MarcosLessi, MarcioFonseca, Leila S.Rigouts, LeenSaad, Maria Helena Féres [UNESP]2014-05-272014-05-272008-07-02Japanese Journal of Infectious Diseases, v. 61, n. 3, p. 231-233, 2008.1344-6304http://hdl.handle.net/11449/70473To highlight the transmission and major phylogenetic clades of Mycobacterium tuberculosis, a retrospective study was carried out at two health facilities in a small agro-industrial area in São Paulo, Brazil, that has a low tuberculosis incidence rate. IS6110-RFLP and spoligotyping were performed on the isolates, with the former revealing that 31.3% (35/112) of strains were clustered. Epidemiological links were found in 16 of the 35 clustered patients and were associated with transmission among patients living in public housing. Spoligotyping grouped 62.8% of the strains. The T genetic family predominated among the isolates. Of interest is that five strains had a pattern characteristic of African or Asian origin (ST535), and two others were of the rare localized type ST1888 (BRA, VEN). In addition, three new types-1889, 1890, and 1891-were identified. Spoligotyping showed that some ST may be circulating to or from Brazil, and RFLP revealed ongoing transmission in inadequately ventilated public-housing buildings. This may point to a failure in tuberculosis control policy.231-233engpyrazinamidestreptomycinAfricaAsiabacterial strainbacterial transmissionbacterium isolateBrazilcommunity livingdrug sensitivitygeographic originhealth care facilityhumanincidenceindustrial areamolecular typingMycobacterium tuberculosisrestriction fragment length polymorphismretrospective studyspoligotypingstrain identificationtuberculosisDNA Transposable ElementsFemaleHumansIncidenceMaleOligonucleotidesPolymorphism, Restriction Fragment LengthPublic HousingTuberculosis, PulmonaryArtigoAcesso aberto2-s2.0-458490847062-s2.0-45849084706.pdf2114570774349859