dos Santos, Fernanda Kolenyak [UNESP]Oyafuso, Marcia Helena [UNESP]Kiill, Charlene Priscila [UNESP]Daflon-Gremião, Maria Palmira [UNESP]Chorilli, Marlus [UNESP]2014-05-272014-05-272013-04-12Current Nanoscience, v. 9, n. 1, p. 159-167, 2013.1573-41371875-6786http://hdl.handle.net/11449/75108The chronic hyperproliferative diseases (CHD) include cancer, precancerous lesions and diseases of unknown etiology such as psoriasis. Various drugs have been used in the treatment of CHD, such as antiproliferative and corticosteroids in general. However, some drugs have properties that limit their effectiveness, such as low solubility in water and low penetration of the skin. Thus, the control of drug release in the skin may improve efficacy and reduce side effects of many drugs used in hyperproliferative diseases. The purpose of this study was to make a systematic review of nanotechnology-based drug delivery systems used against hyperproliferative skin diseases. © 2013 Bentham Science Publishers.159-167engChronic hyperoproliferative diseasesDrug delivery systemsNanotechnologyPsoriasisSkin cancerSkin diseasesSkin treatmentAnti-proliferativeDrug delivery systemDrug releaseSkin cancersSkin diseaseSolubility in watersSystematic ReviewDermatologyDisease controlDrug deliveryDrug interactionsDrug productsDiseasesaminolevulinic acidbenzopsoralen 3 ethoxy carbonyl 2h benzofuro[3,2 e] 1 benzopiran 2 onechitosan derivativeclobetasol propionatecorticosteroidetretinfluorouracilglycerol behenateketoprofenmethotrexatemethoxsalenn sulfonate n,o carboxymethylchitosannanocapsulenanocoatingpaclitaxelphosphatidylcholinepodophyllotoxinpoloxamerpolymerpolymeric nanoparticlepolymethacrylic acidpsoralen derivativeretinoic acidsolid lipid nanoparticlespantidetacrolimustemoporfintriamcinolone acetonideunclassified drugbiodegradabilityburning sensationcell differentiationcell viabilitychronic hyperproliferative diseasecontact dermatitiscreamdermatitisdrug absorptiondrug cytotoxicitydrug delivery systemdrug efficacydrug penetrationdrug releasedrug retentiondrug safetydrug solubilityencapsulationerythemahumaninjection site pruritusiontophoresiskeratinocyteliquid crystalmicroemulsionnanomedicinenanotechnologyphotochemotherapyphotodynamic therapyphotosensitivityprecancerpriority journalpsoriasisPUVAskin allergyskin cancerskin diseaseskin infectionskin penetrationskin tumorstratum corneumsystematic reviewT lymphocytetopical treatmentultraviolet A radiationultraviolet B radiationArtigo10.2174/157341313805117857WOS:000317836000026Acesso restrito2-s2.0-84875934477