Da Silva Planeta, Cleopatra [UNESP]Aizenstein, Moacyr LuizDeLucia, Roberto2014-05-272014-05-271995-01-17Pharmacology Biochemistry and Behavior, v. 50, n. 1, p. 35-40, 1995.0091-3057http://hdl.handle.net/11449/64589Fencamfamine (FCF) is a psychostimulant classified as an indirect dopamine agonist. The conditioning place preference (CPP) paradigm was used to investigate the reinforcing properties of FCF. After initial preferences had been determined, animals were conditioned with FCF (1.75, 3.5, or 7.0 mg/kg; IP). Only at the dose of 3.5 mg/kg FCF produced a significant place preference. Pretreatment with SCH23390 (0.05 mg/kg, SC) or naloxone (1.0 mg/kg SC) 10 min before FCF (3.5 mg/kg; IP) blocked both FCF-induced hyperactivity and CPP. Pretreatment with metoclopramide (10.0 mg/kg; IP) or pimozide (1.0 mg/kg, IP), respectively, 30 min or 4 h before FCF (3.5 mg/kg; IP), which blocked the FCF-induced locomotor activity, failed to influence place conditioning produced by FCF. In conclusion, the present study suggests that dopamine D 1 and opioid receptors are related to FCF reinforcing effect, while dopamine D 2 subtype receptor was ineffective in modifying FCF-induced CPP.35-40engDopamine receptorsFencamfamineOpioid receptorsPlace conditioningReinforcement8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleatedopamine 1 receptordopamine 2 receptordopamine receptordopamine receptor stimulating agentfencamfaminmetoclopramidenaloxoneopiate receptorpimozidepsychostimulant agentreceptor subtypeanimal experimentconditioningcontrolled studydrug antagonismhyperactivityintraperitoneal drug administrationnonhumanplace preferencepriority journalratreinforcementsubcutaneous drug administrationAnimalBinding, CompetitiveCentral Nervous System StimulantsConditioning, OperantMetoclopramideNaloxoneNorbornanesPimozideRatsReceptors, Dopamine D1Receptors, Dopamine D2Receptors, Opioid, muReinforcement (Psychology)Sch-23390AnimaliaArtigo10.1016/0091-3057(94)00236-CWOS:A1995QA54700006Acesso restrito2-s2.0-002879956725147625452809420000-0002-1378-6327