Zague, VivianChorilli, Marlus [UNESP]Ozores Polacow, Maria LuizaMariani Pires-de-Campos, Maria SilviaLeonardi, Gislaine Ricci2014-05-202014-05-202010-01-01Journal of Dispersion Science and Technology. Philadelphia: Taylor & Francis Inc, v. 31, n. 6, p. 756-759, 2010.0193-2691http://hdl.handle.net/11449/7870In vitro skin permeation of hyaluronidase enzyme and the ultrasound (US) effects on cutaneous permeation of this enzyme were investigated. Diffusion cell technique, porcine skins, buffer solution, and a hydrophilic gel+hyaluronidase (100 TUR/g), were used for study. The experimental groups were: gel+enzyme and gel+enzyme+US. The activity of permeated hyaluronidase was determined by turbydimetric method in spectrophotometer at 400nm. Gel+enzyme group permitted a diffusion of 26.89 +/- 3.82 TUR of hyaluronidase in the total time of 240 minutes. However, the other group did not produce significant differences (p0.05) in the same period (13.68 +/- 5.35 TUR). Hyaluronidase permeation through the skin was verified; however US did not cause increase of this enzyme permeation.756-759engHyaluronidasein vitro cutaneous permeationultrasoundArtigo10.1080/01932690903333051WOS:000277725200009Acesso restrito