Rodrigues, Diego S.Mancera, Paulo F.A. [UNESP]Carvalho, TiagoGonçalves, Luiz Fernando [UNESP]2020-12-122020-12-122020-12-15Applied Mathematics and Computation, v. 387.0096-3003http://hdl.handle.net/11449/198024The application of sliding mode control and piecewise smooth vector fields in cancer is an incipient research area. Here we propose a piecewise dynamics to explore chemoimmunotherapeutic strategies. We investigate the dynamic behavior of the discontinuous mathematical model and we observe the occurrence of typical singularities. The on-off treatment strategies are defined in terms of a time-dependent variable such as the number of cancer or immune cells.engCancerChemoimmunotherapyPiecewise smooth vector fieldsTypical singularitiesArtigo10.1016/j.amc.2019.1247822-s2.0-85073559844