Crystallization and preliminary X-ray diffraction analysis of suramin, a highly charged polysulfonated napthylurea, complexed with a myotoxic PLA(2) from Bothrops asper venom

Murakami, M. T.Gava, L. M.Zela, S. P.Arruda, E. Z.Melo, P. A.Gutierrez, J. M.Arni, R. K.2014-05-202014-05-202004-12-01Biochimica Et Biophysica Acta-proteins and Proteomics. Amsterdam: Elsevier B.V., v. 1703, n. 1, p. 83-85, 2004.1570-9639http://hdl.handle.net/11449/37254Suramin is a highly charged polysulfonated napthylurea that interferes in a number of physiologically relevant processes such as myotoxicity, blood coagulation and several kinds of cancers. This synthetic compound was complexed with a myotoxic Lys49 PLA(2) from Bothrops asper venom and crystallized by the hanging-drop vapor diffusion method at 18 degreesC. The crystals belong to the orthorhombic space group P2(1)2(1)2(1), with unit cell parameters a=49.05, b=63.84 and c=85.67 Angstrom, Diffraction data was collected to 1.78 Angstrom. (C) 2004 Elsevier B.V. All rights reserved.83-85engsuraminmyotoxicitysnake venomLys49 PLA(2)sX-ray diffractionCrystallization and preliminary X-ray diffraction analysis of suramin, a highly charged polysulfonated napthylurea, complexed with a myotoxic PLA(2) from Bothrops asper venomArtigo10.1016/j.bbapap.2004.08.009WOS:000225621800010Acesso restrito91625089789458870000-0003-2460-1145