Spinnato, Joseph A.Freire, SalvioPinto e Silva, Joao LuizRudge, Marilza Vieira Cunha [UNESP]Martins-Costa, SergioKoch, Matthew A.Goco, NormanSantos, Cleide de BarrosCecatti, Jose GuilhermeCosta, Roberto [UNESP]Ramos, Jose GeraldoMoss, NancySibai, Baha M.2014-05-202014-05-202008-10-01American Journal of Obstetrics and Gynecology. New York: Mosby-elsevier, v. 199, n. 4, p. 8, 2008.0002-9378http://hdl.handle.net/11449/12232OBJECTIVE: The purpose of this study was to determine if antioxidant supplementation during pregnancy reduces the incidence of premature rupture of the membranes (PROM).STUDY DESIGN: A placebo-controlled, double-blind trial was conducted. PROM and preterm PROM (PPROM) were planned secondary outcomes of the trial. Women between 12(0/7) and 19(6/7) weeks of gestation and diagnosed to have chronic hypertension or a prior history of preeclampsia were randomized to daily treatment with both vitamin C (1000 mg) and E (400 IU) or placebo.RESULTS: Outcome data for PROM were available for 697 of 739 patients. The rates of PROM (37/349 [10.6%] vs 19/348 [5.5%]; adjusted risk ratio [RR] 1.89 [95.42% CI, 1.11-3.23]; P = .015), and PPROM (16/349 [4.6%] vs 6/348 [1.7%]; RR 2.68 [1.07-6.71]; P = .025) were increased in the antioxidant group.CONCLUSION: Contrary to expectations, vitamins C and E supplementation in this dose combination may be associated with an increased risk of PROM and PPROM.8engantioxidantspremature rupture of the membranesprematuritypreventionvitamin Cvitamin EArtigo10.1016/j.ajog.2008.07.011WOS:000260045700042Acesso restrito67586803888350780000-0002-9227-832X