Vendrame-Goloni, C. B.Varella-Garcia, M.Carvalho-Salles, A. B.Ruiz, M. A.Ricci, O.Fett-Conte, A. C.2014-05-202014-05-202003-02-01Cancer Genetics and Cytogenetics. New York: Elsevier B.V., v. 141, n. 1, p. 71-74, 2003.0165-4608http://hdl.handle.net/11449/21328A novel association of t(11;19)(q23;p13) and t(5;16)(q13;q22) was detected by G-banding and spectral karyotyping studies in an 18-year-old patient. While balanced t(11; 19) has been often described in acute myelocytic leukemia (AML) French-American-British Cooperative Group subtypes M4 and M5, this patient was diagnosed with the variant AML-M4 with eosinophilia (AML-M4Eo), which is associated with abnormalities in 16q22 and has good prognosis. However, the patient relapsed after allogeneic transplant and died within 2 years of diagnosis, which suggests that the association of these two translocations correlates with a poor prognosis. This report expands the molecular basis of the variability in clinical outcomes and adds the novel t(5;16)(q13;q22) to the spectrum of chromosome 16q22 abnormalities in AML. (C) 2003 Elsevier B.V. All rights reserved.71-74engArtigo10.1016/S0165-4608(02)00646-5WOS:000180887400011Acesso restrito