Terneux, Eduardo Wladimir Avilés [UNESP]Pontes, Davi AbeidFernandez, Carla Dal BiancoArena, Arielle CristinaPorto, Elaine Manoelade Kempinas, Wilma Grava [UNESP]2014-05-272014-05-272011-02-01Toxicological and Environmental Chemistry, v. 93, n. 2, p. 345-351, 2011.0277-22481029-0486http://hdl.handle.net/11449/72301Ivermectin is one of the most widely used antiparasitic drugs globally. The aim of this study was to evaluate the chronic effects of perinatal exposure to ivermectin on male reproductive parameters in rats. Pregnant rats were treated daily by oral gavage with 0.4 or 1.6 mg kg -1 of ivermectin or vehicle, from gestational day 6 until post-natal day 10. In the adulthood stage, there were significant reductions in the relative testicular weight of rats exposed to the low dose and in relative prostate weight of male rats exposed to the high dose of ivermectin. Furthermore, the animals exposed to the low dose also presented an increased seminal vesicle weight compared to controls. However, neither of the ivermectin doses interfered in daily sperm production, sperm number in testis, or sexual behavior of exposed males. In conclusion, perinatal exposure to ivermectin neither altered the male reproductive system development markedly, nor produced any adverse effects on the parameters evaluated. © 2011 Taylor & Francis.345-351engGestationIvermectinMale reproductive systemParasiticideRatAdverse effectAntiparasitic drugsChronic effectsHigh doseLong-term effectsLow doseMale ratsPregnant ratReproductive systemsSeminal vesicleAnimalsRatsdevelopmental biologydose-response relationshipivermectinmalepollution effectpollution exposurepregnancyreproductive strategyrodentsecondary sexual characteristicsspermAnimaliaRattusArtigo10.1080/02772248.2010.523930Acesso restrito2-s2.0-786498283800729220781785349