Corrêa, Josilene Chaves Ruela [UNESP]Chin, Chung Man [UNESP]Salgado, Hérida Regina Nunes [UNESP]Vianna-Soares, Cristina Duarte2014-05-202014-05-202012-01-01Química Nova. Sociedade Brasileira de Química, v. 35, n. 3, p. 530-534, 2012.0100-4042http://hdl.handle.net/11449/8032The bioassay, first order derivative UV spectrophotometry and chromatographic methods for assaying fluconazole capsules were compared. They have shown great advantages over the earlier published methods. Using the first order derivative, the UV spectrophotometry method does not suffer interference of excipients. Validation parameters such as linearity, precision, accuracy, limit of detection and limit of quantitation were determined. All methods were linear and reliable within acceptable limits for antibiotic pharmaceutical preparations being accurate, precise and reproducible. The application of each method as a routine analysis should be investigated considering cost, simplicity, equipment, solvents, speed, and application to large or small workloads.530-534engfluconazoleliquid chromatographybioassayArtigo10.1590/S0100-40422012000300017S0100-40422012000300017WOS:000303071700017Acesso abertoS0100-40422012000300017.pdf97343336079754130000-0003-4141-0455