Bachiega, T. F. [UNESP]De Sousa, J. P BBastos, J. K.Sforcin, J. M. [UNESP]2014-05-272014-05-272013-09-23Natural Product Research, v. 27, n. 18, p. 1646-1650, 2013.1478-64191478-6427http://hdl.handle.net/11449/76618A possible immunomodulatory/anti-inflammatory effect of Baccharis dracunculifolia (Bd) and its major compound - caffeic acid (Ca) - on cytokines production (IL-1b, IL-6 and IL-10) by murine macrophages was investigated. Cells were incubated with Bd and Ca, and the inhibitory concentrations were tested before or after macrophages challenge with LPS. Bd and Ca stimulated IL-1b and inhibited IL-6 and IL-10 production. In LPS-challenge protocols, Bd prevented LPS action either before or after LPS challenge, whereas Ca prevented LPS effects only after LPS addition. Bd modulatory action on cytokines production may be at least in part mediated by Ca, since it has been shown to inhibit the transcription factor NF-kB. Further studies are still needed to evaluate Bd efficacy in inflammatory diseases, in order to explore its antiinflammatory activity in vivo. © 2013 Taylor & Francis.1646-1650engBaccharis dracunculifoliaCaffeic acidCytokinesImmunomodulation2,2 dimethyl 6 carboxyethenyl 2h 1 benzopyran acidantiinflammatory agentartepilin CBaccharis dracunculifolia extractcaffeic aciddexamethasoneferulic acidimmunoglobulin enhancer binding proteinimmunomodulating agentinterleukin 10interleukin 1betainterleukin 6isosakuranetinlipopolysaccharideplant extractunclassified drugveratraldehydeanimal cellantiinflammatory activitycontrolled studycytokine productiondrug mechanismimmunomodulationin vitro studymousenonhumanperitoneum macrophageplant leafprovocation testArtigo10.1080/14786419.2012.742078WOS:000324087900006Acesso restrito2-s2.0-84884250067