Effects of Low Molecular Weight Sulfated Galactan Fragments From Botryocladia Occidentalis on the Pharmacological and Enzymatic Activity of Spla2 From Crotalus Durissus Cascavella

Toyama, M. H. [UNESP]Toyama, D. O.Torres, V. M.Pontes, G. C.Farias, W. R. L.Melo, F. R.Oliveira, S. C. B. [UNESP]Fagundes, F. H. R. [UNESP]Diz Filho, E. B. S. [UNESP]Cavada, B. S.2014-05-202014-05-202010-11-01Protein Journal. New York: Springer, v. 29, n. 8, p. 567-571, 2010.1572-3887http://hdl.handle.net/11449/336Low molecular weight fragments of sulfated galactans (Boc-5 and Boc-10) from the red algae Botryocladia occidentalis significantly inhibited Crotalus durissus cascavella sPLA2 enzymatic activity. Equimolar ratios of sPLA2 to Boc-5 or Boc-10 resulted in allosteric inhibition of sPLA2. Under the conditions tested, we observed that both Boc-5 and Boc-10 strongly decreased edema, myonecrosis, and neurotoxicity induced by native sPLA2.567-571engBotryocladia occidentalisCrotalus durissus cascavellaSecretory phospholipase A2 (sPLA2)EdemaMyonecrosisEffects of Low Molecular Weight Sulfated Galactan Fragments From Botryocladia Occidentalis on the Pharmacological and Enzymatic Activity of Spla2 From Crotalus Durissus CascavellaArtigo10.1007/s10930-010-9294-9WOS:000284644400005Acesso restrito8573195327542061