Da Costa, Marcelo Cariola CorrêaCarramão, Sílvia SilvaPinto, Patrícia Camarano [UNESP]Milan, Ana Lúcia KoffPannuti, Estela Maia Bellini [UNESP]2014-05-272014-05-272010-06-01Revista Brasileira de Medicina, v. 67, n. 6, p. 195-200, 2010.0034-7264http://hdl.handle.net/11449/71713Aim: This study aimed to evaluate the efficacy of a new topical drug (EF028) in two separate presentations (aerosol and cream) in a comparative way with the already registered medication, Andolba® (benzocaine, benzoxiquina chloride benzeconio, menthol) and the negative control (hygiene), in the analgesic efficacy after episiotomy wound, reducing the requirement for systemic medication. Methods: 60 patients were voluntary post normal vaginal childbirth with episiotomy, were divided into four groups to comparatively assess the action of the product EF028 (cream and aerosol), Andolba® and soap, the efficacy of decreasing painful symptoms from daily use for 2 times a day for seven days. Clinical assessments and subjective pain occurred daily until the third postoperative day and on the 7th postoperative day. Results: The results showed that the drugs promoted a reduction of painful symptoms and there was no statistically significant difference (p <0.05) between presentations of drug EF028 (cream and aerosol) and Andolba® and the three products were significantly higher (p <0.05) to the control. Conclusions: The evaluated drugs EF028 aerosol, EF028 cream and Andolba® had similar efficacy in relieving the painful symptoms of the perineal region in postoperative episiotomy can be considered as indication for postoperative episiotomies. © Copyright Moreira Jr. Editora.195-200porEpisiotomyLocal anesthesiaNormal childbirthanalgesic agentandolbabenzocainebenzocaine plus mentholef 028mentholunclassified drugadultanalgesic activityclinical trialcontrolled clinical trialcontrolled studydrug dosage form comparisondrug efficacydrug screeningepisiotomyfemalehumanmajor clinical studyopen studypain assessmentpostoperative painrandomized controlled trialtreatment responsevaginal deliveryEstudo clínico randomizado e aberto para avaliação de eficácia e superioridade dos medicamentos EF028 aerossol, EF028 creme e Andolba® frente ao tratamento controle e comparativo de não inferioridade entre os medicamentos EF028 aerossol, EF028 creme e Andolba® para avaliação de eficácia na redução da sintomatologia dolorosaA randomized, open-label evaluation of efficacy and superiority of the medications aerosol EF028, cream EF028 and Andolba® front of the control treatment and comparative of non-inferiority between the medications aerosol EF028, cream EF028 and Andolba® to evaluate effectiveness in reducing symptoms painful of episiotomy postoperative in parturient with vaginal child-bearingArtigoAcesso aberto2-s2.0-77954961659