Tavares-Dias, Marcos [UNESP]Martins, Maurício Laterça [UNESP]Canello Schalch, Sérgio Henrique [UNESP]Onaka, Eduardo Makoto [UNESP]Flores Quintana, Carolina Isabel [UNESP]De Moraes, Julieta Rodini Engrácia [UNESP]De Moraes, Flávio Ruas [UNESP]2014-05-272014-05-272002-12-01Acta Scientiarum - Biological and Health Sciences, v. 24, n. 2, p. 547-554, 2002.1415-6814http://hdl.handle.net/11449/67096This paper evaluated the haematological and glycaemic parameters in Piaractus mesopotamicus (Osteichthyes, Characidae) infected with Monogenea Anacanthorus penilabiatus Boeger, Husak & Martins, 1995 (Dactylogyridae) after treatment with 0.50 mg/L and 1.00 mg/L of copper sulphate (CuSO4). The efficacy of the CuSO4 was observed in the first day after administration but not after eight, fifteen or thirty days. The histopathological analyses showed hyperplasia of the epithelium and circulatory changes in the gills. In the first day after treatment significant changes (P<0.05) in the total count of erythrocyte, leucocyte, mean corpuscular haemoglobin concentration (MCHC) were observed. The fishes treated with 0.50 mg/L showed decrease in the haemoglobin levels and in the percentage of neutrophils (P<0.05). The dose of 1.00 mg/L provoked increase of glycaemia but reduction in the lymphocytes percentage when compared with 0.50 mg/L in the 8th day. Fifteen days after 1.00 mg/L treatment, values of mean corpuscular volume (MCV) and special granulocitic cells (S.G.C.) percentage decreased. Nevertheless, increase of total leucocyte number was observed. Thirty days after treatment with 0.50 mg/L showed increased S.G.C. and treatment with 1.00 mg/L showed increased lymphocyte.547-554porCopper sulphateFreshwater fishGlycaemiaHaematologyHistopathologyPiaractus mesopotamicuscopper sulfateglucosehemoglobinanalysisanimal experimentcontrolled studydrug efficacyepitheliumerythrocyte countfishgillglucose blood levelgranulocytehematological parametershemoglobin determinationhistopathologyhyperglycemiahyperplasiainfectionleukocyte countlymphocytemean corpuscular hemoglobinmean corpuscular volumeneutrophilnonhumanobservationsystemic circulationAnimaliaCharacidaeDactylogyridaeMonogeneaOsteichthyesPiaractusPiscesArtigo10.4025/actascibiolsci.v24i0.2358Acesso aberto2-s2.0-00369388502-s2.0-0036938850.pdf