Rocha, Noeme Sousa [UNESP]Barbisan, Luis Fernando [UNESP]De Oliveira, Maria Luiza Cotrim [UNESP]De Camargo, Joo Lauro Viana [UNESP]2014-05-272014-05-272002-03-06Teratogenesis Carcinogenesis and Mutagenesis, v. 22, n. 2, p. 103-111, 2002.0270-3211http://hdl.handle.net/11449/66850Aqueous extracts of the sporophores of eight mushroom species were assessed for their ability to prevent H2O2-induced oxidative damage to cellular DNA using the single-cell gel electrophoresis (Comet) assay. The highest genoprotective effects were obtained with cold (20°C) and hot (100°C) water extracts of Agaricus bisporus and Ganoderma lucidum fruit bodies, respectively. No protective effects were observed with Mushroom Derived Preparations (MDPs) from Flammulina velutipes, Auricularia auricula, Hypsizygus marmoreus, Lentinula edodes, Pleurotus sajor-caju, and Volvariella volvacea. These findings indicate that some edible mushrooms represent a valuable source of biologically active compounds with potential for protecting cellular DNA from oxidative damage. © 2002 Wiley-Liss, Inc.103-111engAgaricus bisporusAnti-oxidantsComet assayGanoderrna lucidumReactive oxygen speciesagaricus bisporus extractAuricularia auricula extractflammulina velutipes extractGanoderma lucidum extracthydrogen peroxidehypsizygus mormoreus extractlentinuloa edodes extractleurotus sajor caju extractmushroom derivative preparationmushroom extractplant extractunclassified drugvolvariella volvacea extractantioxidant activityDNA damagegel electrophoresisHong Konghumanhuman cellmushroommutagenesisoxidative stresspriority journalAgaricalesComet AssayDNA DamageDNA, NeoplasmFungal ProteinsHydrogen PeroxideMutagenicity TestsOxidation-ReductionOxidative StressReactive Oxygen SpeciesTumor Cells, CulturedAgaricusAuriculaAuricularia auricula-judaeBasidiomycotaFlammulinaFlammulina velutipesGanodermaGanoderma lucidumHypsizygusHypsizygus marmoreusLentinulaLentinula edodesPleurotusPleurotus sajor-cajuVolvariella volvaceaArtigo10.1002/tcm.10008Acesso restrito2-s2.0-0036179148327852811265225760777359184692840000-0002-8188-8149