Holanda, Bruno B.C. [UNESP]Alarcon, Rafael T. [UNESP]Guerra, Renan B. [UNESP]Rinaldo, Daniel [UNESP]Spazzini, Fabiola C.R. [UNESP]Castro, Ricardo A.E.Bannach, Gilbert [UNESP]2019-10-062019-10-062018-10-01Journal of Analytical and Applied Pyrolysis, v. 135, p. 76-84.0165-2370http://hdl.handle.net/11449/189766In this work, the thermal decomposition of mebendazole (MBZ) was studied to elucidate divergent data found in the literature concerning the thermal behavior of this drug. To this end, thermogravimetry-differential scanning calorimetry (TG-DSC), differential scanning calorimetry (DSC), evolved gas analysis (EGA), and DSC-photovisual analysis were employed to fully evaluate the polymorphic form A of MBZ. Our results showed that mebendazole undergoes mass loss starting at 205 °C with the release of methanol and carbon monoxide. Characterization of the main thermal decomposition product of MBZ through mid-infrared spectroscopy (MIR), proton nuclear magnetic resonance ( 1 H NMR), high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), and powder X-ray diffraction (PXRD) indicated the formation of 2-amino-5-benzoylbenzimidazole (MBZ-A). Kinetic parameters for MBZ and MBZ-A were also evaluated and shown herein.76-84engCoupled TG-FTIRDSC-photovisual analysisMebendazoleThermal behaviorArtigo10.1016/j.jaap.2018.09.017Acesso aberto2-s2.0-85054002940