Zornoff, Leonardo Antonio Mamede [UNESP]Paiva, Sergio Alberto Rupp de [UNESP]Trovanelli Tornero, M. T. [UNESP]Stateri Carvalho, M. S. [UNESP]Ferreira Tucci, P. J. [UNESP]2014-05-272014-05-271995-01-01Arquivos Brasileiros de Cardiologia, v. 64, n. 3, p. 225-229, 1995.0066-782Xhttp://hdl.handle.net/11449/64560Purpose - To analyse the influence of mannitol added to Krebs-Henseleit (KH) solution on the myocardium edema and myocardial function. Methods - Isolated rat heart under isovolumetric contractions studied according to Langendorff's technique were perfused with KH solution at constant flow during 90 min. The coronary perfusion pressure, diastolic and systolic pressures were recorded at every 15 min. At the end of the experiment, myocardium water content was measured in hearts perfused with KH solution (group I, n = 9) and in hearts perfused with KH solution plus 8 mM mannitol (group II, n = 8). These results were compared to non-perfused control heart (n = 9). Results - Myocardial water content was statistically higher in group I (80.8 ± 1.3%) compared to group II (78.1 ± 0.7%) and control group (75.5 ± 0.5%). Systolic arterial pressure was statistically higher in group I (86.2 ± 11.5 mmHg) compared to group II (72.7 ± 21.1 mmHg). There was no difference in the diastolic pressure between the two groups. Coronary perfusion pressure (Pp) increased progressively during the experiment in both groups. However, Pp was lower in group II than in group I. Conclusion - Mannitol added to KH solution significantly attenuates the myocardium edema in the isolated perfused rat heart.225-229pormannitolmyocardial-edemacardioplegic agentglucosekrebs henseleit solutionKrebs-Henseleit solutionosmotic diuretic agenttrometamolanimal tissuecontrolled studycoronary reperfusionedemaheart functionmyocardial diseasenonhumanratanimalblood pressurebody watercomparative studydrug effectheart contractionheart edemain vitro studymalemultivariate analysispathophysiologyrat strainAnimalBlood PressureBody WaterCardioplegic SolutionsComparative StudyDiuretics, OsmoticEdema, CardiacEnglish AbstractGlucoseIn VitroMaleMannitolMultivariate AnalysisMyocardial ContractionRatsRats, WistarTromethamineINFLUENCIA DO ACRESCIMO DE MANITOL A SOLUCAO NUTRIENTE NO DESEMPENHO MECANICO E NO GRAU DE EDEMA MIOCARDICO DE CORACOES ISOLADOS DE RATOSInfluence of mannitol added to the perfusion solution on mechanical properties and myocardial edema of isolated rat heartsArtigoAcesso aberto2-s2.0-00290791652-s2.0-0029079165.pdf5016839015394547