Oliveira-Neto, Helenisa HelenaSouza, Pedro Paulo Chaves de [UNESP]Da Silva, Márcio Roberto BarbosaMendonça, Elismauro FranciscoSilva, Tarcília AparecidaBatista, Aline Carvalho2014-05-272014-05-272013-02-01Tumor Biology, v. 34, n. 1, p. 65-70, 2013.1010-42831423-0380http://hdl.handle.net/11449/74457The purpose of this study is to determine the expression of CCL19, CCL21, and CCR7 in samples of oral squamous cell carcinoma (OSCC) and their relationship with clinical and microscopic parameters. A comparative analysis was made of the mRNA expression of these chemokines and receptor in OSCC and normal oral mucosa. The immunoexpression of CCR7, CCL19, and CCL21 was also verified in OSCC and lymph nodes. Statistical significance was accepted at P < 0.05. Similar levels of CCR7, CCL19, and CCL21 mRNA in OSCC and normal oral mucosa were seen. A low expression of CCL19 and CCL21 in the intra- and peritumoral regions was observed. Scarce CCL19+ and CCL21+ cells were also noted in metastatic and non-metastatic lymph nodes. No association was found between the expression of these chemokines and clinical and microscopic parameters. Our findings would suggest that CCL19 and CCL21 may not be associated with cervical lymph node metastasis or other clinical and microscopic factors in OSCC. © 2012 International Society of Oncology and BioMarkers (ISOBM).65-70engCCL19CCL21CCR7ChemokineLymph nodeMetastasisOral squamous cell carcinomachemokinechemokine receptorchemokine receptor CCR7macrophage inflammatory protein 3betamessenger RNAmonocyte chemotactic protein 5adultagedcell countcell proliferationcervical lymph nodeclinical articleclinical featurecomparative studycontrolled studydisease associationfemalehumanhuman cellhuman tissuelymph node metastasismalemetastasis potentialmouth mucosamouth squamous cell carcinomanucleotide sequenceoncological parameterspriority journalprotein expressionprotein functiontumor localizationCarcinoma, Squamous CellChemokine CCL19Chemokine CCL21FemaleHumansLymph NodesLymphatic MetastasisMaleMiddle AgedMouth NeoplasmsReceptors, CCR7RNA, MessengerTreatment OutcomeThe expression of chemokines CCL19, CCL21 and their receptor CCR7 in oral squamous cell carcinoma and its relevance to cervical lymph node metastasisArtigo10.1007/s13277-012-0511-3WOS:000313875400009Acesso restrito2-s2.0-84872779578