Barros, Antonia Patricia Oliveirade Melo Alencar, Cristiane [UNESP]de Melo Pingarilho Carneiro, Alexandrada Silva Pompeu, DanielleBarbosa, Gabriela MonteiroAraújo, Jesuína Lamartine NogueiraSilva, Cecy Martins2022-04-282022-04-282022-02-01Clinical Oral Investigations, v. 26, n. 2, p. 1299-1307, 2022.1436-37711432-6981http://hdl.handle.net/11449/222135Objectives: This study evaluated the effect of photobiomodulation (PBM) combined with 8% strontium acetate (SA8%) in the treatment of dentin hypersensitivity (DH) in non-carious lesions and analyzed the risk factors with the patient’s quality of life. Methods: Eighty teeth with DH were randomly allocated into four treatment groups (n = 20): G1, PBM imitation + toothpaste with no active ingredient; G2, PBM imitation + toothpaste with SA8%; G3, PBM + toothpaste without the active ingredient; and G4, PBM + toothpaste with SA8%. Participants were provided with a questionnaire on the experience of dentin hypersensitivity (QEDH) to assess the impact of desensitizing treatment on health-related quality of life (HRQL). Friedman and Kruskal–Wallis tests were used for intra- and intergroup comparisons, and Wilcoxon and Mann–Whitney tests were used to analyze HRQL. All analyses used significance levels of 5%. Results: Intergroup comparisons revealed a significant difference (p < 0.05); G4 had the best response in terms of HD reduction in G4 compared to the other groups on the 7th day of assessment (T3). Only G4 showed a statistically significant difference (p < 0.05) in the reduction of EDH for intragroup analysis. Conclusion: The combination of therapies was more effective in reducing DH than the isolated use of these strategies. Clinical relevance: The combination of therapies is effective in the treatment of DH.1299-1307engDentin hypersensitivityQuality of lifeRisk factorsTherapyArtigo10.1007/s00784-021-04104-22-s2.0-85111942105