Duarte Byrro, Ricardo MartinsMiyashita, Denisede Albuquerque, Verônica Batista [UNESP]Velascoe Cruz, Antônio Augustoda Silva Cunha Júnior, Armando2014-05-272014-05-272009-07-01Arquivos Brasileiros de Oftalmologia, v. 72, n. 4, p. 444-450, 2009.0004-27491678-2925http://hdl.handle.net/11449/71053Purpose: The present study aimed to evaluate an injectable extended-release formulation of prednisolone acetate (PA) for orbital administration. Methods: Microspheres (MEs) of poly-ε-caprolactone (PCL) containing PA were developed by the method of solvent evaporation. The MEs obtained were characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), encapsulation efficiency and in vitro release profile. The in vivo release profile was evaluated in rabbits after periocular injection of an aqueous suspension of MEs. The local biocompatibility of the system was verified by histopathologic analysis of the deployment region. Results: After MEs preparation, morphological analysis by SEM showed the feasibility of the employed method. The content of PA encapsulated was 43 ± 7% and can be considered as satisfactory. The system characterization by DSC technique, in addition to confirm the system stability, did not indicate the existence of interaction between the drug and the polymer. The in vitro release study showed the prolonged-release features of the developed system. Preliminary in vivo study showed the absence of local toxicity and confirmed the prolonged release profile of PA from MEs, suggesting the viability of the developed system for the treatment of orbital inflammatory diseases. Conclusion: The results obtained in this work are relevant and accredit the system developed as a possible alternative to the treatment of inflammatory orbitopathy.444-450porAbsorbable implantsDelayed-action preparationsDrug carriersDrug delivery systemsDrug implants/administration & dosageOrbital diseases/drug therapyPolymersPrednisolone/administration dosageantiinflammatory agentbiomaterialdrug carrierdrug derivativemicrospherepolycaprolactonepolyesterprednisoloneprednisolone acetateanimalchemistrydelayed release formulationdifferential scanning calorimetrydrug effectfemalematerials testingrabbitscanning electron microscopyvitreous bodyAnimalsAnti-Inflammatory AgentsBiocompatible MaterialsCalorimetry, Differential ScanningDelayed-Action PreparationsDrug CarriersFemaleMaterials TestingMicroscopy, Electron, ScanningMicrospheresPolyestersPrednisoloneRabbitsVitreous BodyArtigo10.1590/S0004-27492009000400004S0004-27492009000400004Acesso aberto2-s2.0-740491265282-s2.0-74049126528.pdf