Migliato, K. F. [UNESP]Chorilli, Marlus [UNESP]Scarpa, M. V. [UNESP]Moreira, Raquel Regina Duarte [UNESP]Correa, Marcos Antonio [UNESP]Isaac, Vera Lucia Borges [UNESP]Salgado, Hérida Regina Nunes [UNESP]2014-05-272014-05-272009-05-01Revista de Ciencias Farmaceuticas Basica e Aplicada, v. 30, n. 2, p. 197-202, 2009.1808-45322179-443Xhttp://hdl.handle.net/11449/70998Dimorphandra mollis Benth., Compositae, false barbatimão, has been used topically as a healing, astringent and antibacterial. In this study, antibacterial activity was verified on liquid soap containing glycolic extract of D. mollis (DGE) at different concentrations (8, 15 and 20%) and at different pH levels (6 and 8). Five soap formulations (F) were prepared: F1 - tryclosan (0.1%), F2 - DGE (8%), F3 - DGE (15%), F4 - DGE (20%) and F5 - without preservatives. Bark of D. mollis were dried in a circulating air oven and ground. The rude extracts were prepared by turbo extraction with ethanol. After screening, the extract were concentrated in rotating evaporator, lyophilized and resuspended in propileneglycol to obtain the glycolic extract. The antimicrobial activity was verified by diffusion in agar method, using cylinder in plate. Plates containing Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli were incubated at 37°C for 24 hours. After incubation, the results were analysed with a pachymeter, observing the bacterial grouth inhibition halo diameter. It was verified that the liquid soap containing tryclosan caused on inhibition of bacterial growth at both pH levels; the soaps without preservatives and containing DGE, independently of the concentration and pH levels used, did not present antibacterial activity.197-202porAntibacterial activityDimorphandra mollis Benth.Liquid soapantiinfective agentdimorphandra mollis extractglycolic acidplant extractpreservativesoapunclassified drugagar diffusionantibacterial activitybacterial growthbarkconcentration (parameters)dimorphandra mollisdrug inhibitionEscherichia coligrowth inhibitionincubation temperaturemedicinal plantnonhumanpHPseudomonas aeruginosaStaphylococcus aureusArtigoAcesso aberto2-s2.0-786498964592-s2.0-78649896459.pdf33160116888299434842462513285606142712599671628277103444618649240000-0002-4253-0320