Witaicenis, Aline [UNESP]de Oliveira, Ellen Cristina Souza [UNESP]Tanimoto, Alexandre [UNESP]Zorzella-Pezavento, Sofia Fernanda Gonçalves [UNESP]de Oliveira, Silvio Luis [UNESP]Sartori, Alexandrina [UNESP]Di Stasi, Luiz Claudio [UNESP]2018-12-112018-12-112018-01-25Chemico-Biological Interactions, v. 280, p. 59-63.1872-77860009-2797http://hdl.handle.net/11449/1756164-methylesculetin is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities. Recent studies have shown that 4-methylesculetin has a promising potentiality to treat inflammatory diseases, especially those related to reactive oxygen species, as inflammatory bowel disease. Based on this, the present study aims to investigate the intestinal anti-inflammatory activity of 4-methylesculetin in dextran sulfate sodium (DSS) model. For this purpose, mice received DSS 5% for 5 days followed by 2 days of filtered tap water. Treated groups received orally 5 or 25 mg/kg of 4-methylesculetin daily since the first day. Macroscopic, microscopic and biochemical parameters were evaluated. 4-methylesculetin (25 mg/kg) improved microscopic parameters, decreased MPO activity, reduced the colonic levels of IL-6 and counteracted GSH depletion when compared with DSS-control group. Our results show the intestinal anti-inflammatory activity of 4-methylesculetin in DSS model, which is related to its antioxidant and anti-inflammatory properties. This way, 4-methylesculetin, is a new potential compound for treatment of both types of IBD.59-63eng4-methylesculetinAntioxidantCoumarinDSSInflammatory bowel diseaseMiceArtigo10.1016/j.cbi.2017.12.006Acesso aberto2-s2.0-850377021642-s2.0-85037702164.pdf