Garcia, Valdir Gouveia [UNESP]Takano, Rodrigo Yuji [UNESP]Fernandes, Leandro Araújo [UNESP]Almeida, Juliano Milanezi de [UNESP]Theodoro, Letícia Helena [UNESP]2014-05-272014-05-272010-12-01Inflammopharmacology, v. 18, n. 6, p. 293-301, 2010.0925-46921568-5608http://hdl.handle.net/11449/71990Lumiracoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) approved for the relief of symptoms of chronic inflammatory conditions. The aim of this study was to evaluate the effects of this specific inhibitor of COX-2 as adjunctive treatment on induced periodontitis in rats. Periodontal disease was induced at the first mandibular molar of 60 rats. After 7 days, the ligature was removed and all animals were submitted to scaling and root planing (SRP) along with local irrigation with saline solution and were divided into 2 groups: SRP (n = 30)-received subcutaneous injections of 1 mg/kg of body weight/day of saline solution for 3 days and; SRP + L (n = 30)-received subcutaneous injections of 1 mg/kg of body weight/day of Lumiracoxib for 3 days. Ten animals in each group were killed at 7, 15, and 30 days. The histological description was performed and the histometric values were statistically analyzed. In Group SRP + L, the histometric analysis (0.58 ± 0.08, 0.64 ± 0.06, and 0.56 ± 0.10 mm 2) showed less bone loss (p < 0.05) than Group SRP (1.52 ± 0.08, 1.55 ± 0.09, and 1.49 ± 0.24 mm 2) at 7, 15, and 30 days, respectively. Within the limits of this study it can be concluded that subcutaneous application of specific inhibitor of COX-2 was a beneficial adjunctive treatment for periodontal diseases induced in rats. © 2010 Springer Basel AG.293-301engAlveolar bone lossAnimal studiesLumiracoxibPeriodontal disease/therapyPeriodontitisRatscollagen fibercyclooxygenase 2 inhibitorlumiracoxibsodium chloridealveolar bone lossanimal experimentanimal modelbone tissuecontrolled studyhistopathologymalemorphometricsnonhumanperiodontal diseaseperiodontitispreventive dentistrypriority journalratwound irrigationAlveolar Bone LossAnimalsChemotherapy, AdjuvantCyclooxygenase 2 InhibitorsDental ScalingDiclofenacInjections, SubcutaneousMaleRats, WistarRoot PlaningArtigo10.1007/s10787-010-0059-zAcesso restrito2-s2.0-7865133439040689213692331254774447118127346