De Souza, Fayene Zeferino Ribeiro [UNESP]De Almeida, Amanda Cosmo [UNESP]Ferreira, Patrícia Osorio [UNESP]Fernandes, Richard Perosa [UNESP]Caires, Flávio Junior [UNESP]2022-04-282022-04-282022-01-01Ecletica Quimica, v. 47, n. 1, p. 64-75, 2022.1678-46180100-4670http://hdl.handle.net/11449/223320Quercetin (QUE) is a nutraceutical compound that exhibits pharmacological properties such as antioxidant, cardioprotective, anti-ulcer, and anti-inflammatory effects. Although QUE is well-known for its benefits, its efficacy is limited due to low solubility. Thus, cocrystallization acts as an interesting approach to improve the solubility - among other properties - of this compound. In this work, cocrystallization screening was applied through neat grinding (NG) and liquid-assisted grinding (LAG), in which QUE and four cocrystal formers (benzamide, picolinamide, isonicotinamide, and pyrazinoic acid) were tested. The precursors and QUE-coformer systems were characterized using thermoanalytical techniques (TG-DTA), X-ray powder diffraction (XRPD), and Fourier transform infrared (FTIR) spectroscopy. The results showed the formation of QUE cocrystals with picolinamide and isonicotinamide coformers in a 1:1 stoichiometric ratio. Furthermore, although coformers are isomers, spectroscopic and thermal data suggest that the supramolecular synthons involved in cocrystallization are different.64-75engCocrystallizationFlavonoidMechanochemistryNutraceuticalThermal analysisScreening of coformers for quercetin cocrystals through mechanochemical methodsArtigo10.26850/1678-4618eqj.v47.1.2022.p64-752-s2.0-85123410556