Oliveira, Cristiano Claudino [UNESP]Marques, Mariângela Esther Alencar [UNESP]Nóbrega, Vinicius Cardoso [UNESP]2018-12-112018-12-112018-03-01Anais Brasileiros de Dermatologia, v. 93, n. 2, p. 256-258, 2018.1806-48410365-0596http://hdl.handle.net/11449/176263Primary cutaneous lymphoepithelioma-like carcinoma is a rare disease with low metastatic potential. Its morphologic and pathological features are similar to those of nasopharyngeal lymphoepithelial carcinoma. We report the case of a 60-year-old man with an infrapalpebral pearly papule, measuring 0.6 cm in diameter. The lesion was excised with a clinical hypothesis of basal cell carcinoma or squamous cell carcinoma. Histopathological analysis revealed a malignant neoplasm with syncytial arrangement of cells with vesicular nuclei, associated with dense lymphocytic infiltrate. Immunohistochemistry revealed cytokeratin-positive cells (AE1/AE3) and p63 protein, indicating epithelial histogenesis and squamous differentiation. A negative Epstein-Barr virus test result was achieved by immunohistochemistry. Primary lymphoepithelioma-like carcinoma of the skin is a differential diagnosis of lesions with prominent inflammatory infiltrates.256-258engImmunohistochemistryPathologySkin neoplasmsArtigo10.1590/abd1806-4841.20187205S0365-05962018000200256Acesso aberto2-s2.0-85046427410S0365-05962018000200256.pdf7528116925519142