Silva, GabrielLima, Felipe TeixeiraSeba, VivianeMendes Lourenco, Ana LauraLucas, Thaise GraminhaAndrade, Bianca Vieira deTorrezan, Guilherme Silva [UNESP]Polaquini, Carlos Roberto [UNESP]Garcia, Marcelo EngraciaCouto, Lucelio BernardesBestetti, Reinaldo BulgarelliFranca, Suzelei de CastroFachin, Ana LuciaRegasini, Luis Octavio [UNESP]Marins, Mozart2018-11-262018-11-262018-02-01Molecules. Basel: Mdpi, v. 23, n. 2, 10 p., 2018.1420-3049http://hdl.handle.net/11449/163924Gastric cancer is one of the most frequent malignant tumors in the world. The majority of patients are diagnosed with metastatic gastric cancer, which has a low survival rate. These data reinforce the importance of studying the anticancer activity of new molecules with the potential to suppress gastric cancer metastasis. Curcumin is a well-studied compound that has demonstrated anti-metastatic effects. Here we investigated if CH-5, a curcumin derivative compound, has anti-metastatic properties in the human gastric cancer cell line HGC-27. Firstly, we found that CH-5 decreased viability and induced apoptosis in HGC-27 cells in a dose-dependent manner. Additionally, CH-5 suppressed the migration and invasion of HGC-27 cells by downregulating the expression and collagenase activity of matrix metalloproteinase 2 in a dose-dependent manner. In conclusion, CH-5 showed anticancer activities, including the induction of apoptosis, and the suppression of migration and invasion in HGC-27 cells, suggesting that CH-5 can be a lead molecule for the development of anti-metastatic drugs for gastric cancer therapy.10enggastric cancercurcuminmatrix metalloproteinase 2migrationinvasionapoptosisArtigo10.3390/molecules23020279WOS:000426436300059Acesso abertoWOS000426436300059.pdf