Amphibian secretions for drug discovery studies: A search for new antiparasitic and antifungal compounds

Tempone, André GustavoMelhem, Márcia de Souza CarvalhoPrado, Frederico OliveiraMotoie, GabrielaHiramoto, Roberto MitsuyoshiAntoniazzi, Marta MariaHaddad, Celio Fernando Baptista [UNESP]Jared, Carlos2014-05-272014-05-272007-01-10Letters in Drug Design and Discovery, v. 4, n. 1, p. 67-73, 2007.1570-1808http://hdl.handle.net/11449/69512The antiparasitic and antifungal activities of nine amphibian skin secretions were studied in different in vitro models. Seven secretions presented a considerable antiprotozoan activity and one showed promising results against Candida sp. These results can be the basis for the development of new drugs, especially for neglected parasitic diseases. © 2007 Bentham Science Publishers Ltd.67-73engAmphibiansAntimicrobialLeishmaniaPeptidesSecretionsTrypanosomaamino acid oxidaseamphibian proteinantifungal agentantiparasitic agentbenznidazolemeglumine antimonatepentamidinepyrimethamineAmphibiaanimal cellanimal experimentanimal modelanimal tissueCandidacontrolled studydose responsedrug designdrug effectdrug researchenzyme activitygrowth inhibitionmousenonhumanpriority journalskin secretionAmphibian secretions for drug discovery studies: A search for new antiparasitic and antifungal compoundsArtigo10.2174/157018007778992856WOS:000242910300012Acesso restrito2-s2.0-338459671530458077399058762