Silva, Raphael Tristão CruvinelGuidotti-Takeuchi, MicaelaPeixoto, Jéssica Laura MirandaDemarqui, Fernanda Manaia [UNESP]Mori, Ananda PaulaDumont, Carolyne FerreiraFerreira, Gabriella Rayane AparecidaPereira, Gabriele de MenezesRossi, Daise AparecidaCorbi, Pedro PauloPavan, Fernando Rogério [UNESP]Rezende Júnior, Celso de OliveiraMelo, Roberta Torres deGuerra, Wendell2023-07-292023-07-292023-05-01Molecules, v. 28, n. 9, 2023.1420-3049http://hdl.handle.net/11449/249955This work describes the preparation, characterization and antimicrobial activity of four palladium(II) complexes, namely, [Pd(meg)(1,10-phen)] 1, [Pd(meg)(PPh3)2] 2, [Pd(og)(1,10-phen)] 3 and [Pd(og)(PPh3)2] 4, where meg = methyl gallate, og = octyl gallate, 1,10-phen = 1,10-phenanthroline and PPh3 = triphenylphosphine. As to the chemical structures, spectral and physicochemical studies of 1–4 indicated that methyl or octyl gallate coordinates a palladium(II) ion through two oxygen atoms upon deprotonation. A chelating bidentate phenanthroline or two triphenylphosphine molecules complete the coordination sphere of palladium(II) ion, depending on the complex. The metal complexes were tested against the Mycobacterium tuberculosis H37Rv strain and 2 exhibited high activity (MIC = 3.28 μg/mL). As to the tests with Campylobacter jejuni, complex 1 showed a significant effect in reducing bacterial population (greater than 7 log CFU) in planktonic forms, as well as in the biomass intensity (IBF: 0.87) when compared to peracetic acid (IBF: 1.11) at a concentration of 400 μg/mL. The effect provided by these complexes has specificity according to the target microorganism and represent a promising alternative for the control of microorganisms of public health importance.enganti-infective drugsantibacterial activityCampylobacter jejuniMycobacterium tuberculosispalladium(II) complexesArtigo10.3390/molecules280938872-s2.0-85159310229