Kitagawa, Rodrigo RezendeVilegas, Wagner [UNESP]Carlos, Iracilda Zeppone [UNESP]Raddi, Maria Stella Gonçalves [UNESP]2014-05-202014-05-202011-12-01Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 21, n. 6, p. 1084-1088, 2011.0102-695Xhttp://hdl.handle.net/11449/7977Large number of quinones has been associated with antitumor, antibacterial, antimalarial and antifungal activities. In this work we describe the effect of the naphthoquinone, 5-methoxy-3,4-dehydroxanthomegnin, on murine tumor cells (LP07 and LM2) and its immunomodulatory effect on nitric oxide (NO) production on LPS-stimulated macrophages. The results have shown that 5-methoxy-3,4-dehydroxanthomegnin was a significant inhibitor of LPS-stimulated NO generation from macrophage (inhibition percentage ranged from 97.4 to 98.9%) and a strong cytotoxic agent against both tumor cells LP07 and LM2 (CI50 6.2±0.36 µM and 74.6±1.9 µM, respectively). These results indicate that the 5-methoxy-3,4-dehydroxanthomegnin may show promising activity in the treatment of murine breast and lung cancer by immunomodulatory and antiproliferative activities.1084-1088eng5-methoxy-3,4-dehydroxanthomegnincytotoxic activityimmunomodulatorynaphthoquinoneArtigo10.1590/S0102-695X2011005000136S0102-695X2011000600019WOS:000297216900019Acesso abertoS0102-695X2011000600019.pdf79278772243268370000-0003-3032-2556