De Toledo, Antônio Carlos [UNESP]Kawano, Paulo Roberto [UNESP]Yamamoto, Hamilto Akihissa [UNESP]Guerra, Rodrigo [UNESP]Filho, Fernando Ferreira Gomes [UNESP]Pajolli, Pedro Ivo Rochetti [UNESP]Amaro, João Luiz [UNESP]Cardoso, Luiz Eduardo MacedoSampaio, Francisco José2020-12-122020-12-122019-01-01Acta Cirurgica Brasileira, v. 34, n. 9, 2019.1678-26740102-8650http://hdl.handle.net/11449/199781Purpose: To evaluate the effects of tadalafil (TD) in preventing histological alterations of the corpus cavernosum caused by isolated lesions of cavernous nerve (ILCN) and artery (ILCA) in rats. Methods: Fifty male Wistar rats were randomly assigned in five groups: G1: Control; G2: Bilateral ILCN; G3: Bilateral ILCA; G4: ILCN+TD; G5: ILCA+TD. The cavernous bodies were submitted to histomorphometry, immunohistochemistry and biochemical analysis. Results: Nerve density was significantly higher in G2 and G4 compared to control (22.62±2.84 and 19.53±3.47 vs. 15.72±1.82; respectively, p<0.05). Smooth muscle density was significantly lower in G2 and G3 in comparison to G1 (12.87±1.90 and 18.93±1.51 vs. 21.78±1.81, respectively; p<0.05). A significant decrease in the sinusoidal lumen area was observed in G2 compared to controls (5.01±1.62 vs. 9.88±3.66, respectively; p<0.05) and the blood vessel density was increased in G2 and G3 (29.32±4.13 e 20.80±2.47 vs. 10.13±2.71, p<0.05). Collagen density was higher in G3 compared to G1 (93.76±15.81 vs. 64.59±19.25; p<0.05). Conclusions: Histomorphometric alterations caused by ILCN were more intense than those produced by vascular injury, but the collagen analyses showed more fibrosis in animals with ILCA. TD was effective in preventing the majority of the alterations induced by the periprostatic bundle injury.engCollagenElastinErectile DysfunctionRatsTadalafilArtigo10.1590/s0102-865020190090000001S0102-86502019000900213Acesso aberto2-s2.0-85076166902S0102-86502019000900213.pdf