Saad, Wilson Abrão [UNESP]Camargo, Gabriela Pavan de Arruda [UNESP]Camargo, Luiz Antonio de Arruda [UNESP]2014-05-272014-05-271996-11-01Pharmacology. Basel: Karger, v. 53, n. 5, p. 281-288, 1996.0031-7012http://hdl.handle.net/11449/64872The effects of clonidine on sodium and potassium excretions were examined after previous administration of prazosin (an α 1-adrenergic receptor antagonist) and yohimbine (an α 2-adrenergic receptor antagonist) into the ventromedial nucleus of the hypothalamus of conscious rats. Clonidine injected into the ventromedial nucleus of the hypothalamus induced inhibitory and facilitatory effects on the urinary sodium and potassium excretions. The results suggest that facilitatory effects of clonidine on natriuresis and kaliuresis are mediated through activation of α 1-adrenoceptors and that inhibitory effects require α(2A)-adrenoceptors.281-288engClonidinePotassium excretionPrazosinSodium excretionVentromedical nucleus, hypothalamusYohimbinealpha 1 adrenergic receptoralpha 2A adrenergic receptoralpha adrenergic receptor stimulating agentclonidinepotassium ionprazosinsodium ionyohimbineanimal experimentcontrolled studyintracerebral drug administrationkaliuresismalenatriuresisnonhumanpotassium urine levelpriority journalratsodium urine levelstimulationthalamus ventral nucleusAdrenergic alpha-AntagonistsAnimalsDose-Response Relationship, DrugHypothalamusKidneyMalePotassiumRatsSodiumArtigo10.1159/000139440WOS:A1996VY81500002Acesso restrito2-s2.0-10544222836