Sousa, Marlos G.Paulino-Junior, Daniel [UNESP]Pascon, Joao P. E. [UNESP]Pereira-Neto, Glaucia B. [UNESP]Carareto, RobertaChampion, Tatiana [UNESP]Camacho, Aparecido Antonio [UNESP]2014-05-202014-05-202011-08-01Canadian Veterinary Journal-revue Veterinaire Canadienne. Ottawa: Canadian Vet Med Assoc, v. 52, n. 8, p. 869-874, 2011.0008-5286http://hdl.handle.net/11449/1793This study assessed the effects of a single intracoronary injection of autologous stem cells on the cardiac function of dogs with Chagas cardiomyopathy. Bone-marrow-derived stem cells were delivered into the right and left coronary arteries of 5 mature dogs with mildly compromised cardiac function due to chronic Chagas cardiomyopathy. Blood pressure and electrocardiographic and echocardiographic parameters were recorded at monthly intervals for 6 mo in the 3 dogs that survived. Although no changes were observed in the electrocardiogram and blood pressure, there was a significant increase in peak velocity of aortic flow 3 mo after stem cell transplantation. Pre-ejection period, isovolumic relaxation time, and the Tei index of myocardial performance were reduced significantly 4 mo after the procedure. All significant changes persisted to the end of the study. The results suggest that the transplantation of autologous bone-marrow-derived stem cells into the coronary arteries of dogs with Chagas cardiomyopathy may have a beneficial effect but the small number of dogs studied was a limitation.869-874engArtigoWOS:000293990600005Acesso restrito9642688764978907