Pieroni, FabianoLourenço, Dayse M.Morelli, Vânia M.Maffei, Francisco Humberto de Abreu [UNESP]Zago, Marco A.Franco, Rendrik F.2014-05-272014-05-272007-05-21Thrombosis Research, v. 120, n. 2, p. 221-229, 2007.0049-3848http://hdl.handle.net/11449/69670Introduction: Venous thrombosis (VT) and inflammation are two closely related entities. In the present investigation we assessed whether there is a relation between genetic modifiers of the inflammatory response and the risk of VT. Materials and methods: 420 consecutive and unrelated patients with an objective diagnosis of deep VT and 420 matched controls were investigated. The frequencies of the following gene polymorphisms were determined in all subjects: TNF-α- 308 G/A, LT-α+ 252 A/G, IL-6-174 G/C, IL1-ra 86 bp VNTR, IL-10-1082 A/G and CD-31 125 C/G. Results: Overall odds ratio (OR) for VT related to TNF-α- 308 G/A, LT-α+ 252 A/G, IL-6-174 G/C, A1 allele (4 bp repeat) of the IL1-ra 86 bp VNTR, IL-10-1082 A/G and CD-31 125 C/G were respectively: 1.0 (CI95: 0.8-1.5), 1.3 (CI95: 1.0-1.7), 1.1 (CI95: 0.9-1.5), 1.6 (CI95: 1-2.5), 1.2 (CI95: 0.8-1.7) and 0.8 (CI95: 0.6-1.1). A possible interaction between polymorphisms was observed only for the co-inheritance of the mutant alleles of the LT-α+ 252 A/G and IL-10-1082 G/A polymorphisms (OR = 2; CI95: 1.1-3.8). The risk of VT conferred by factor V Leiden and FII G20210A was not substantially altered by co-inheritance with any of the cytokine gene polymorphisms. Conclusions: Cytokine gene polymorphisms here investigated did not significantly influence venous thrombotic risk. © 2006 Elsevier Ltd. All rights reserved.221-229engCoagulationCytokinesInflammationPolymorphismsThrombosisVenous thromboembolismblood clotting factor 11blood clotting factor 5 LeidenCD31 antigencytokineinterleukin 1 receptor blocking agentinterleukin 10interleukin 6lymphotoxintumor necrosis factor alphacardiovascular riskdeep vein thrombosisgenetic polymorphisminflammationmajor clinical studymedical researchBase SequenceCase-Control StudiesDNA PrimersInterleukin 1 Receptor Antagonist ProteinInterleukin-10Interleukin-6Lymphotoxin-alphaMiddle AgedOdds RatioPolymorphism, GeneticTumor Necrosis Factor-alphaVariation (Genetics)Venous ThrombosisArtigo10.1016/j.thromres.2006.09.015Acesso restrito2-s2.0-34248512217