Amorim, Renée Laufer [UNESP]Pinczowski, P. [UNESP]Neto, R. T. [UNESP]Rahal, Sheila Canevese [UNESP]2014-05-202014-05-202010-03-01Veterinary and Comparative Oncology. Malden: Wiley-blackwell Publishing, Inc, v. 8, n. 1, p. 23-27, 2010.1476-5810http://hdl.handle.net/11449/41111Vascular endothelial growth factor (VEGF) and prostaglandin E2 (PGE-2) appear to play a critical role in tumour neovascularization. In this study, we have investigated the expression of VEGF and PGE-2 in 53 canine cutaneous mast cell tumours (MCTs). Immunohistochemistry of tissue sections revealed that VEGF and PGE-2 were expressed in all mast cell tumours studied. When the expression patterns of VEGF and PGE-2 were compared with tumour grade according to Patnaik criteria, the only significant correlation observed was between PGE-2 staining intensity and tumour pathological grade, with grade II and III tumours having higher PGE-2 staining, both in intensity and percentage of cells stained, than grade I tumours (P < 0.05).23-27engangiogenesiscaninemast cell tumourPGE-2VEGFArtigo10.1111/j.1476-5829.2009.00202.xWOS:000273912000003Acesso restrito979582902210810514974332653901940000-0002-9211-4093