Bonini-Domingos, Ana Carolina [UNESP]Bonini-Domingos, Claudia Regina [UNESP]Lacida, Edi Carlos [UNESP]Mattos, Cinara de Cássia Brandão deMattos, Luiz Carlos de2015-04-272015-04-272014Biomarkers and Genomic Medicine, v. 6, p. 99-104, 2014.2214-0247http://hdl.handle.net/11449/122712This study was undertaken to assess the frequency of angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism in patients with type 2 diabetes mellitus. A total of 162 patients with type 2 diabetes and 160 individuals without this disease were analyzed. From the diabetes group, 81 patients with cardiovascular risk (according to American Diabetes Association parameters) were selected to form another subgroup. For polymorphism identification, two polymerase chain reactions were performed: one reaction to identify all genotypes and a second one to confirm the presence of the I allele. The observed genotype frequencies were as follows: diabetes group I/I (19.1%), I/D (52.5%), D/D (28.4%); control group I/I (12.5%), I/D (55.6%), D/D (31.9%); and diabetes with cardiovascular risk group I/I (16.0%), I/ D (59.3%), D/D (24.7%). No statistically significant difference was observed between the allelic and genotypic frequencies in the analyzed groups. Previous studies reported an association between the D allele and type 2 diabetes in Caucasian and East Asian populations. However, in mixed populations, such as those found in Brazil, such an association was not found. This fact does not discard the need for more studies on the frequencies of this polymorphism in the Brazilian population and the associations with risk factors, which can compromise the quality of life of diabetes patients99-104engACE polymorphismangiotensin converting enzyme polymorphismgenetic polymorphismI/D polymorphismtype 2 diabetArtigo10.1016/j.bgm.2014.06.001Acesso aberto32794280661767190000-0002-4603-9467