Livonesi, Marcia CristinaMoro de Sousa, Ricardo LuizBadra, Soraya JaburMoraes Figueiredo, Luiz Tadeu2014-05-202014-05-202007-08-01Antiviral Research. Amsterdam: Elsevier B.V., v. 75, n. 2, p. 121-128, 2007.0166-3542http://hdl.handle.net/11449/2890Oropouche, Caraparu, Guama, Guaroa and Tacaiuma viruses (Orthobunyavirus genus) cause human febrile illnesses and/or encephalitis. To achieve a therapeutical agent to prevent and/or treat these diseases we evaluated the antiviral action of Interferon-alpha (IFN-alpha) on these orthobunyaviruses. In vitro results showed that all the studied orthobunyaviruses are susceptible to antiviral action of IFN-alpha, but this susceptibility is limited and dependent on both concentration of drug and treatment period. In vivo results demonstrated that IFN-alpha present antiviral action on Oropouche and Guaroa viruses when used as a prophylactic treatment. Moreover, a treatment initiated 3 It after infection prevented the death of Guaroa virus infected-mice. Additionally, mortality of mice was related to the migration and replication of viruses in their brains. Our results suggest that IFN-alpha could be potentially useful in the prevention of diseases caused by Oropouche virus and in the prevention and/or treatment of diseases caused by Guaroa virus. (C) 2007 Elsevier B.V. All rights reserved.121-128enginterferon-alphaOrthobunyavirusBunyaviridaeplaque assaysuckling miceArtigo10.1016/j.antiviral.2007.01.158WOS:000246956500004Acesso restrito