Calazans, S. G.Alves, C. E.F. [UNESP]Zanetti, N. M.Conforti, V. A.Santilli, J.Anjos, D. S.Magalhães, G. M.2018-12-112018-12-112016-01-01Pakistan Veterinary Journal, v. 36, n. 1, p. 124-126, 2016.0253-8318http://hdl.handle.net/11449/168386A 12-year-old male Maltese dog was presented with a history of shivering episodes. Radiographs revealed a mass in the left kidney that was histopathologically classified as a renal cell carcinoma. After nephrectomy, pelvic limbs became paralyzed. Spinal cord and lung metastases were detected via histopathological examination and confirmed by immunohistochemistry. Both pan-cytoketatin and Ki67 assays tested positive in the kidney, lung, and spinal cord. Interestingly, COX- 2 had mild immunoreactivity in the kidney, but its labeling was intense in the spinal cord and lung. Though seemingly rare, the spinal cord may possibly be a focus point for metastasis of renal cell carcinomas. Because symptoms can easily be misunderstood, late diagnoses would not be uncommon and may hinder clinical management of the disease.124-126engCanineMetastasisPan-cytoketatinRenal neoplasmSpinal cordArtigoAcesso restrito2-s2.0-84958175874