Silva, Geraldo H. [UNESP]Araújo, Angela Regina [UNESP]Telesa, Helder L. [UNESP]Trevisana, Henrique C. [UNESP]Bolzani, Vanderlan da Silva [UNESP]Young, Maria C. M.Pfenning, Ludwig H.Eberlind, Marcos N.Haddad, RenatoCosta-Netoe, Claudio M.2014-05-272014-05-272005-11-01Journal of the Brazilian Chemical Society, v. 16, n. 6 B, p. 1463-1466, 2005.0103-5053http://hdl.handle.net/11449/68473Two new metabolites, ethyl 2,4-dihydroxy-5,6-dimethylbenzoate (1) and phomopsilactone (2) were isolated from Phomopsis cassiae, an endophytic fungus in Cassia spectabilis. Their structures were elucidated by 1D and 2D NMR, MS and IR spectral data. Compounds 1 and 2 displayed strong antifungal activity against the phytopatogenic fungi Cladosporium cladosporioides and C. sphaerospermum, as well as cytotoxicity against human cervical tumor cell line (HeLa), in in vitro assays. ©2005 Sociedade Brasileira de Química.1463-1466engAntifungal activityCassia spectabilisCytotoxic metabolitesEndophytic fungiPhomopsis cassiaeArtigo10.1590/S0103-50532005000800029S0103-50532005000800029WOS:000234078700029Acesso aberto2-s2.0-308444456322-s2.0-30844445632.pdf003757905408316044840836852516730000-0001-7616-9652