Gimenes, C. [UNESP]Gimenes, R. [UNESP]Rosa, C. M. [UNESP]Xavier, N. P. [UNESP]Campos, D. H. S. [UNESP]Fernandes, A. A. H. [UNESP]Cezar, M. D. M. [UNESP]Guirado, G. N. [UNESP]Cicogna, A. C. [UNESP]Takamoto, A. H. R. [UNESP]Okoshi, M. P. [UNESP]Okoshi, K. [UNESP]2015-12-072015-12-072015Journal Of Diabetes Research, v. 2015, p. 1-10, 2015.2314-6753http://hdl.handle.net/11449/131094We evaluated the effects of a low intensity aerobic exercise protocol on cardiac remodeling and myocardial function in diabetic rats. Wistar rats were assigned into four groups: sedentary control (C-Sed), exercised control (C-Ex), sedentary diabetes (DM-Sed), and exercised diabetes (DM-Ex). Diabetes was induced by intraperitoneal injection of streptozotocin. Rats exercised for 9 weeks in treadmill at 11 m/min, 18 min/day. Myocardial function was evaluated in left ventricular (LV) papillary muscles and oxidative stress in LV tissue. Statistical analysis was given by ANOVA or Kruskal-Wallis. Echocardiogram showed diabetic groups with higher LV diastolic diameter-to-body weight ratio and lower posterior wall shortening velocity than controls. Left atrium diameter was lower in DM-Ex than DM-Sed (C-Sed: 5.73 ± 0.49; C-Ex: 5.67 ± 0.53; DM-Sed: 6.41 ± 0.54; DM-Ex: 5.81 ± 0.50 mm; P < 0.05 DM-Sed vs C-Sed and DM-Ex). Papillary muscle function was depressed in DM-Sed compared to C-Sed. Exercise attenuated this change in DM-Ex. Lipid hydroperoxide concentration was higher in DM-Sed than C-Sed and DM-Ex. Catalase and superoxide dismutase activities were lower in diabetics than controls and higher in DM-Ex than DM-Sed. Glutathione peroxidase activity was lower in DM-Sed than C-Sed and DM-Ex. Conclusion. Low intensity exercise attenuates left atrium dilation and myocardial oxidative stress and dysfunction in type 1 diabetic rats.1-10engArtigo10.1155/2015/457848Acesso abertoPMC4609864.pdf94189701035641374463138671998432159097157630942026509175PMC4609864